Anti-BCL10 [151] | Ximbio 151821 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-BCL10 [151]

catalog :

151821

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8915

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-BCL10 [151]

Catalogue Number :

151821

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

Bcl10

Reactivity :

Human

Relevance :

BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.

Host :

Mouse

Immunogen :

Full-length recombinant BCL-10 protein

Subclass :

IgG1 kappa

Myeloma Used :

NS0

Strain :

Balb/c

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction, Metabolism

Notes :

IHC-P: 1/25 - 1/100 in an ABC method. Antibody incubation period of 30 minutes at room temperature is recommended. Perform heat mediated antigen retrieval with 10mM citrate buffer, pH 6.0 before commencing with IHC staining protocol.

more info or order :

Ximbio product webpage