Anti-BCL11A [BCL11A/123] | Ximbio 151750 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-BCL11A [BCL11A/123]

catalog :

151750

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

53335

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-BCL11A [BCL11A/123]

Catalogue Number :

151750

Applications :

IHC IP WB

Antigen/Gene or Protein Targets :

BCL11A (EVI9, CTIP1)

Reactivity :

Human and Rat

Relevance :

BCL11A is a Krüppel zinc-finger transcription factor that was identified originally from a chromosome translocation in aggressive B-cell chronic lymphocytic leukaemia. The gene may function as both an oncogene and a tumour suppressor. Alternative splicing generates multiple isoforms, the BCL11AXL being the largest and most abundant transcript. The protein is differentially expressed during B-cell development and is strongly expressed in plasmacytoid dendritic cells. The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen.

Host :

Mouse

Immunogen :

C-terminus of extra long isoform of BCL11A, BCL11AXL (aa 637-835)

Subclass :

IgG1

Positive Control :

Tonsil (in B cells and plasmcytoid dendritic cells), Neurones and nuclei of some epithelium

Molecular Weight (kDa) :

Predicted 91KDa

Myeloma Used :

P3/NS1/1-Ag4.1

Research Area :

Cancer, Epigenetics & Nuclear Signalling, Neurobiology

Notes :

IHC: Frozen use neat supernatant IHC: Paraffin use 1/10 supernatant WB: use neat supernatant.

more info or order :

Ximbio product webpage