Anti-MCM5 [A2.4B4.B7.A11.A8] | Ximbio 151727 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-MCM5 [A2.4B4.B7.A11.A8]

catalog :

151727

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10130

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-MCM5 [A2.4B4.B7.A11.A8]

Catalogue Number :

151727

Applications :

IF WB

Antigen/Gene or Protein Targets :

Mini Chromosome Maintenance protein5 (MCM5)

Synonyms :

Minichromosome Maintenance Complex Component 5; P1-CDC46; CDC46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12

Reactivity :

Human

Relevance :

MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal.

Host :

Mouse

Immunogen :

Bacterially expressed His-tagged human Mcm5 (amino acids 367-582)

Subclass :

IgG2b

Positive Control :

HeLa, HL60

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

20% OPI serum

Strain :

Balb/c

Research Area :

Epigenetics & Nuclear Signalling

Notes :

Also known as: 352.4B4 or A2.4B4.B7.A11.A8

more info or order :

Ximbio product webpage