Anti-pTpY Cdk1 [CP3.2] | Ximbio 151684 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-pTpY Cdk1 [CP3.2]

catalog :

151684

clonality :

monoclonal

host :

house mouse

conjugate :

nonconjugated

clone name :

380246

reactivity :

Xenopus laevis

application :

western blot, ELISA

more info or order :

Ximbio product webpage

product information

Name :

Anti-pTpY Cdk1 [CP3.2]

Catalogue Number :

151684

Applications :

ELISA WB

Antigen/Gene or Protein Targets :

Cdk1

Synonyms :

Cyclin-Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A; Cell Cycle Controller CDC2; CDKN1

Reactivity :

Mammalian and Xenopus laevis

Relevance :

Cyclin dependent kinase 1 (Cdk1) regulates cell cycle progression. It is active as a heterodimeric complex with cyclins. Cdk1 associates with cyclin A at the end of S phase and targets proteins such as p53, BARD1, and BRCA2 involved in cell cycle progression, and others involved in DNA replication. At the end of the G2 phase, Cdk1 associates with cyclin B1 and B2 to phosphorylate multiple protein targets required for transition from G2 to M phase, and progression through M phase. Cdk1 itself undergoes phosphorylation at Thr14 and Tyr15 by PKMYT1, which prevents nuclear translocation of Cdk1. Cdk1 is also phosphorylated at Tyr15 by WEE1/2 which inhibits both Cdk1 activity and transition from G2 to M phase. Conversely, dephosphorylation of Thr14 and Tyr15 by CDC25A/B activates Cdk1 and triggers mitosis. Cdk1 may also regulate epigenetic gene silencing through phosphorylation of EZH2 and maintenance of histone H3 lysine 27 trimethylation, which has been implicated in cancer

Host :

Mouse

Immunogen :

Peptide - EKIGEGpTpYGVVYKGC - pT represents phosphorylated Thr14 and pY represents phosphorylated Tyr15

Subclass :

IgG1

Positive Control :

Cultured cell line

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

10% FCS

Research Area :

Cancer, Cell Cycle

more info or order :

Ximbio product webpage