Anti-Transmembrane protein [IF3/A10] | Ximbio 151609 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Transmembrane protein [IF3/A10]

catalog :

151609

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

100131211

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-Transmembrane protein [IF3/A10]

Catalogue Number :

151609

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

K15 (a putative transmembrane protein similar to LMP2A)

Reactivity :

Human and Virus

Relevance :

Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.

Host :

Mouse

Immunogen :

Recombinant protein

Subclass :

IgG1

Molecular Weight (kDa) :

50 (full length)

Myeloma Used :

P3X63Ag8.653

Strain :

Balb/c

Research Area :

Apoptosis and Programmed Cell Death, Protein Degradation, Virology

more info or order :

Ximbio product webpage