Anti-CDX1 [123a] | Ximbio 151546 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CDX1 [123a]

catalog :

151546

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1044

reactivity :

human

application :

western blot, immunocytochemistry, chromatin immunoprecipitation, ChIP-Seq

more info or order :

Ximbio product webpage

product information

Name :

Anti-CDX1 [123a]

Catalogue Number :

151546

Applications :

ChIP IF WB ChIP-seq

Antigen/Gene or Protein Targets :

CDX1

Synonyms :

Caudal Type Homeobox 1

Reactivity :

Human

Relevance :

CDX1 is an intestine-specific transcription factor with a role in directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. Cdx1 positively regulates its own expression in the small intestine and colon of fetus and adult and promotes cellular growth and differentiation in epithelial intestinal cells. A reduction in human Cdx1 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways.

Host :

Mouse

Immunogen :

Human CDX-1 N-terminal peptide

Subclass :

IgG1

Positive Control :

HT55, LS174T, RCM1

Molecular Weight (kDa) :

Myeloma Used :

P3/NS1/1-Ag4.1

Recommended Growing Conditions :

RPMI 1640 + 10% FCS + HAT

Strain :

Balb/c

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Epigenetics & Nuclear Signalling

Notes :

Notes from originator: Clone 123a has a degree of cross reactivity with a determinant of different molecular weight when applied by WB and IHC in fibroblasts and smooth muscle cells. The cross reacting product does not appear in epithelial cells (or at least is significantly weaker).

more info or order :

Ximbio product webpage