Anti-Integrin aVb6 [AvB6 53a.2] | Ximbio 151543 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Integrin aVb6 [AvB6 53a.2]

catalog :

151543

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

3655

reactivity :

human

application :

immunocytochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Integrin aVb6 [AvB6 53a.2]

Catalogue Number :

151543

Applications :

FACS IF IP Fn

Antigen/Gene or Protein Targets :

Integrin alpha v/beta 6

Reactivity :

Human

Relevance :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.

Host :

Rat

Immunogen :

Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.

Subclass :

IgG2a

Positive Control :

BT20 breast carcinoma, original immunogen.

Recommended Growing Conditions :

RPMI 1640 + 3% FCS

Research Area :

Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Stem Cell Biology

Notes :

Recommended Concentration: 10ug/ml

more info or order :

Ximbio product webpage