Anti-EBV Latent Membrane Protein 1 [CS 1-4] | Ximbio 151471 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-EBV Latent Membrane Protein 1 [CS 1-4]

catalog :

151471

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CS 1-4

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

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product information

Name :

Anti-EBV Latent Membrane Protein 1 [CS 1-4]

Catalogue Number :

151471

Applications :

IHC IF IP WB

Antigen/Gene or Protein Targets :

Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)

Reactivity :

Virus

Relevance :

EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells. CS 1-4 is specific for Epstein-Barr virus infected cells expressing the latent membrane protein (LMP). This antibody is four pooled monoclonal antibodies that collectively detect LMP's encoded by each of 20 geographically distinct EBV isolates.

Host :

Mouse

Subclass :

IgG1

Positive Control :

EBV transformed lymphoblastoid cell lines

Molecular Weight (kDa) :

57-66

Myeloma Used :

P3X63Ag8.653

Research Area :

Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Virology

more info or order :

Ximbio product webpage