Anti-FBW7 [FBOX 3a9/1] | Ximbio 151461 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-FBW7 [FBOX 3a9/1]

catalog :

151461

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9968

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-FBW7 [FBOX 3a9/1]

Catalogue Number :

151461

Applications :

FACS IHC IF IP WB

Antigen/Gene or Protein Targets :

F-box/WD repeat-containing protein 7 (FBW7, Cdc4)

Synonyms :

F-Box And WD Repeat Domain Containing 7; F-Box Protein FBX30; SEL-10; Fbx30; HCdc4; FBW7; Hago; Homolog Of C Elegans Sel-10; F-Box Protein SEL-10; Archipelago Homolog; F-Box Protein FBW7; Archipelago; FBXO30; FBXW6; CDC4; FBW6; AGO

Reactivity :

Human and Mouse

Relevance :

SCF (Skp, Cullin, F-box containing complex) ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 thus negatively regulates several key oncoproteins. Accordingly, FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice.

Host :

Mouse

Immunogen :

Synthetic peptide of human sequence

Subclass :

IgG1

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

E4 + 5% FCS

Research Area :

Cancer, Protein Degradation

more info or order :

Ximbio product webpage