Anti-Integrin a4 [BU49] | Ximbio 151439 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Integrin a4 [BU49]

catalog :

151439

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3676

reactivity :

human

application :

immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Integrin a4 [BU49]

Catalogue Number :

151439

Applications :

FACS IP

Antigen/Gene or Protein Targets :

Integrin alpha 4 (CD49d)

Synonyms :

Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR

Reactivity :

Human

Relevance :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 (CD49d) is a 150 kDa protein characterised by a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain. Hetrodimers are formed with integrin beta 1 and 7. BU49 induces phosphorylation of a cAMP response element-binding protein (CREB) in the human monocyte-like cell line, U937.

Host :

Mouse

Immunogen :

Hicett myeloma cell line

Subclass :

IgG1

Molecular Weight (kDa) :

150

Recommended Growing Conditions :

RPMI 1640 + 10% FCS

Research Area :

Adhesion, Cardiovascular, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

more info or order :

Ximbio product webpage