Anti-nNav 1.5 [4G8:1G7] | Ximbio 151409 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-nNav 1.5 [4G8:1G7]

catalog :

151409

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3778

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-nNav 1.5 [4G8:1G7]

Catalogue Number :

151409

Applications :

FACS IHC IF WB

Antigen/Gene or Protein Targets :

Neonatal Nav1.5 (Voltage gated Sodium Channel Nav1.5)

Reactivity :

Human

Relevance :

Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5.

Host :

Mouse

Immunogen :

Peptide (14mer) from an extracellular domain of Nav1.5 - VSENIKLGNLSALR

Subclass :

IgM

Positive Control :

Cell lines over expressing Nav1.5, e.g Nav 1.5-HEK293 cells

Molecular Weight (kDa) :

180-200

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 5% FCS

Strain :

CD1

Research Area :

Cellular Transport, Neurobiology

Notes :

4G8:1G7 is recommended for Western blotting and Immunocytochemistry using 2ug/ml and 10ug/ml, respectively.

more info or order :

Ximbio product webpage