Anti-Integrin aEb7 [BP6] | Ximbio 151379 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Integrin aEb7 [BP6]

catalog :

151379

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3655

reactivity :

human

application :

immunohistochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-Integrin aEb7 [BP6]

Catalogue Number :

151379

Applications :

IHC IP

Antigen/Gene or Protein Targets :

Integrin alpha E/ß7 (CD103)

Reactivity :

Human

Relevance :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha E/beta7 (aE/b7) is a heterodimer comprising a 150kDa alpha E chain and a 120kDa beta 7 chain. The expression of Integrin aE/b7 defines a developmentally important subset of T cells, namely mucosal T cells including all intraepithelial lymphocytes and ~20% of lamina propria T cells. Integrin aE/b7 is also a selective marker for intestinal intra-epithelial T-cells. BP6 may be used in the diagnosis of enteropathy-associated lymphoma and hairy cell leukaemia.

Host :

Mouse

Immunogen :

Hairy cell spleen lysate

Subclass :

IgG1 kappa

Myeloma Used :

P3/NS1/1-Ag4.1

Recommended Growing Conditions :

RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT

Research Area :

Adhesion

Notes :

Ultroser G can be used at 1% if the cells are not growing well.

more info or order :

Ximbio product webpage