Anti-CR2 [21A/5] | Ximbio 151354 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CR2 [21A/5]

catalog :

151354

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1365

reactivity :

human

application :

immunohistochemistry, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-CR2 [21A/5]

Catalogue Number :

151354

Applications :

FACS IHC

Antigen/Gene or Protein Targets :

Complement component (3d/Epstein Barr virus) receptor 2 (CR2, CD21)

Synonyms :

Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor; EBV Receptor; C3DR; CD21 Antigen; CVID7; SLEB9; CD21; Cr2; CR

Reactivity :

Human

Relevance :

CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B-cell activation. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, CR2 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.

Host :

Mouse

Immunogen :

CD21

Subclass :

IgG1

Myeloma Used :

P3/NS1/1-Ag4.1

Recommended Growing Conditions :

RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT

Research Area :

Cell Signaling & Signal Transduction, Immunology

Notes :

Ultroser G can be used at 1% if the cells are not growing well.

more info or order :

Ximbio product webpage