Anti-Spastin [Sp 3G11/1] | Ximbio 151320 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Spastin [Sp 3G11/1]

catalog :

151320

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6683

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-Spastin [Sp 3G11/1]

Catalogue Number :

151320

Applications :

ChIP ELISA IHC IF WB

Antigen/Gene or Protein Targets :

Spastin

Reactivity :

Human, Mouse and Rat

Relevance :

Spastin is thought have a role in microtubule dynamics through its function as a microtubule-severing protein. It is localised to the centrosome of neuronal cells but is not found in glial cells. Mutation in the ATPase binding domain of spastin causes hereditary spastic paraplegias (HSP), a large group of clinically similar disorders. Mutant forms of spastin are generally found throughout the cytoplasm rather then within the nucleus. There are two splice isoforms of spastin (one without exon4) and two alternative ATG start sites, which may determine the localisation of the translate protein.

Host :

Mouse

Immunogen :

Recombinant human spastin

Subclass :

IgG2a

Positive Control :

HeLa cell or rat brain extract

Molecular Weight (kDa) :

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 5% FCS

Strain :

Balb/c

Research Area :

Cardiovascular, Cell Cycle, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism, Neurobiology

Notes :

Suggested dilution for western blot: 1:500

more info or order :

Ximbio product webpage