Anti-PHD3 [EG188e/d5] | Ximbio 151315 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-PHD3 [EG188e/d5]

catalog :

151315

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

112399

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-PHD3 [EG188e/d5]

Catalogue Number :

151315

Applications :

IHC WB

Antigen/Gene or Protein Targets :

Prolyl Hydroxylase 3 (PHD3)

Reactivity :

Human

Relevance :

PHD3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, hydroxylates HIF-1 alpha at Pro-564, and also hydroxylates HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. It promotes cell death through a caspase-dependent mechanism

Host :

Mouse

Immunogen :

Residues 1-100 of human PHD3

Subclass :

IgG1

Positive Control :

ZR75 cells on hypoxic induction

Molecular Weight (kDa) :

27.3

Myeloma Used :

P3/NS1/1-Ag4.1

Recommended Growing Conditions :

RPMI + 10% FCS + 5% CO2

Strain :

Balb/c

Research Area :

Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

more info or order :

Ximbio product webpage