Anti-PHD2 [366G/76/3] | Ximbio 151314 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-PHD2 [366G/76/3]

catalog :

151314

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

54583

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-PHD2 [366G/76/3]

Catalogue Number :

151314

Applications :

IHC WB

Antigen/Gene or Protein Targets :

Prolyl Hydroxylase 2 (PHD2)

Reactivity :

Human

Relevance :

366G/76/3 recognises human prolyl hydroxylase 2 (PHD2), a 46kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.

Host :

Mouse

Immunogen :

Residues 1-24 of PHD2

Subclass :

IgG1

Positive Control :

MCF7 cells

Molecular Weight (kDa) :

46.1

Myeloma Used :

P3/NS1/1-Ag4.1

Recommended Growing Conditions :

RPMI + 10% FCS + 5% CO2

Strain :

Balb/c

Research Area :

Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

more info or order :

Ximbio product webpage