Anti-PHD1 [PHD112/G7] | Ximbio 151313 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-PHD1 [PHD112/G7]

catalog :

151313

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

112398

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-PHD1 [PHD112/G7]

Catalogue Number :

151313

Applications :

IHC WB

Antigen/Gene or Protein Targets :

Prolyl Hydroxylase 1 (PHD1)

Reactivity :

Human

Relevance :

PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.

Host :

Mouse

Immunogen :

Full length recombinant human PHD1

Subclass :

IgM

Positive Control :

MCF7 cells

Molecular Weight (kDa) :

43.6

Myeloma Used :

P3/NS1/1-Ag4.1

Strain :

Balb/c

Research Area :

Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

more info or order :

Ximbio product webpage