Anti-TIGAR [9C10] | Ximbio 151312 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-TIGAR [9C10]

catalog :

151312

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

57103

reactivity :

human

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-TIGAR [9C10]

Catalogue Number :

151312

Applications :

ChIP IP WB

Antigen/Gene or Protein Targets :

TIGAR

Reactivity :

Human

Relevance :

TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis.

Host :

Mouse

Immunogen :

A 15-amino acid peptide corresponding to the exon COOH-terminal region of human TIGAR protein (CMNLQDHLNGLTETR).

Subclass :

IgG2b

Molecular Weight (kDa) :

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 10% foetal Clone I (Hyclone cat no. SH30080.03)

Research Area :

Apoptosis and Programmed Cell Death, Cancer, DNA Damage and Repair

Notes :

Suggested dilution of 1:5000

more info or order :

Ximbio product webpage