Anti-Phospho MDM2 (Ser186) [2G2 2.2] | Ximbio 151309 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Phospho MDM2 (Ser186) [2G2 2.2]

catalog :

151309

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4193

reactivity :

human

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-Phospho MDM2 (Ser186) [2G2 2.2]

Catalogue Number :

151309

Applications :

Antigen/Gene or Protein Targets :

Murine Double Minute 2 protein (MDM2), Phosphorylated (Serine 186)

Reactivity :

Human

Relevance :

MDM2's principal function is the ubiquitination and degradation of p53 tumour suppressor protein, promoting progression through the cell cycle and cell survival. MDM2 is over-expressed in many tumours. The phosphorylation of serines 166 and 186 is necessary for MDM2's translocation into the nucleus, thereby facilitating interaction with p53.

Host :

Mouse

Immunogen :

Peptide QRKRHKS(p)DSIS. S(p) represent a phosphorylated serine. This peptide represents the portion of MDM2 around Serine 186

Subclass :

IgG1

Positive Control :

Breast carcinoma

Molecular Weight (kDa) :

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 5% FCS

Strain :

Balb/c

Research Area :

Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage