product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-MDM2 [SMP14]
catalog :
151295
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4193
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
Ximbio product webpage
product information
Name :
Anti-MDM2 [SMP14]
Catalogue Number :
151295
Applications :
ELISA IHC IF IP WB
Antigen/Gene or Protein Targets :
Murine Double Minute 2 protein (MDM2)
Reactivity :
Human
Relevance :
MDM2 is over-expressed in many tumours. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein.
Host :
Mouse
Immunogen :
Synthetic peptide CSRPSTSSRRRAISE (residues 154-167 in human MDM2) cross-linked to KLH using glutaldehyde.
Subclass :
IgG2a
Positive Control :
Breast carcinoma
Myeloma Used :
P3X63Ag8.653
Recommended Growing Conditions :
DMEM + 5% FCS
Strain :
Balb/c
Research Area :
Adhesion, Cancer, Cell Cycle, Epigenetics & Nuclear Signalling
Notes :
SMP14 monoclonal antibody also recognises a peptide epitope around Thr-216 of murine MDM2 (when Thr-216 is unphosphorylated) see Zhang & Prives, 2001 for further details. SMP14 also cross reacts with some cytokeratins (6, 14 & 16). This is only a problem when working with certain epithelial cells and not fibroblasts.
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com