Anti-Integrin a4 [7.2] | Ximbio 151218 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Integrin a4 [7.2]

catalog :

151218

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3676

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Integrin a4 [7.2]

Catalogue Number :

151218

Applications :

FACS IHC IP WB

Antigen/Gene or Protein Targets :

Integrin alpha 4 (VLA-4; CD49d)

Reactivity :

Human

Relevance :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 Combines with beta-1 integrin to form the Integrin alpha4/beta1 lymphocyte homing receptor: Very Late Antigen 4 (VLA-4). VLA-4 plays a major role in lymphocyte extravasation, via binding to VCAM on endothelial cells. VLA-4 also binds fibronectin and mediates homotypic and heterotypic cell-cell adhesion between lymphocytes.

Host :

Mouse

Immunogen :

Human melanoma line DX3

Subclass :

IgG1

Positive Control :

U937 human histiocytic lymphoma cell line

Research Area :

Adhesion, Cardiovascular, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

Notes :

Recommended for Histology on unfixed tissue culture cells.

more info or order :

Ximbio product webpage