product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-HPV16 E1/E4 [TVG 402]
catalog :
151171
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5627
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation
more info or order :
Ximbio product webpage
product information
Name :
Anti-HPV16 E1/E4 [TVG 402]
Catalogue Number :
151171
Applications :
ELISA IHC IP WB
Antigen/Gene or Protein Targets :
Human Papilloma Virus 16 early proteins 1 and 4 (HPV16 E1/E4)
Reactivity :
Human papilloma virus
Relevance :
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer case. E1 and E2 are proteins involved in the regulation of viral DNA replication. TVG 402 and TVG 403 were the first antibodies against HPV16 E1 & E4 and should complement those already available to E7 and L1 for the screening of frozen sections of clinical biopsies. They will be of value in monitoring the progress of HPV infection from benign lesions to invasive cancer.
Host :
Mouse
Immunogen :
Antigen for hybridoma production was expressed as a b galactosidase fusion protein using the pEX expression system and was consequently cleaved to release the E1/E4 polypeptide.
Subclass :
IgG1
Molecular Weight (kDa) :
10
Myeloma Used :
NS0
Recommended Growing Conditions :
RPMI 1640 + 10% FCS, may need suppliment with SIGMA ITS medium.
Research Area :
Cancer, Virology
Notes :
The epitope recognised by this antibody survived brief fixation in 5% formaldehyde, but not prolonged fixation.
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com