product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-MUC1 [SM3]
catalog :
151161
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4582
reactivity :
human
application :
ELISA, immunohistochemistry, FACS
more info or order :
Ximbio product webpage
product information
Name :
Anti-MUC1 [SM3]
Catalogue Number :
151161
Applications :
ELISA FACS IHC
Antigen/Gene or Protein Targets :
Mucin1 (MUC1)
Synonyms :
ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
Reactivity :
Human
Relevance :
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.
Host :
Mouse
Immunogen :
Hydrogen fluoride deglycosylated milk mucin.
Subclass :
IgG2a kappa
Positive Control :
MCF7 cells (FACS) or human breast carcinoma (IHC)
Myeloma Used :
P3X63Ag8.653
Recommended Growing Conditions :
RPMI 1640 + 10% FCS
Strain :
Balb/c
Research Area :
Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction
Notes :
The product of the MUC1 gene is the polymorphic epithelial mucin. SM3 reacts with a core protein epitope defined as PDTRP.
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com