Anti-PCNA [PC10] | Ximbio 151148 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-PCNA [PC10]

catalog :

151148

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3054

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-PCNA [PC10]

Catalogue Number :

151148

Applications :

FACS IHC IF IP WB

Antigen/Gene or Protein Targets :

Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein

Synonyms :

Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2

Reactivity :

Human, Insect and Schizosaccharomyces pombe

Relevance :

PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value.

Host :

Mouse

Immunogen :

Protein A-PCNA fusion obtained from pC2T.

Subclass :

IgG2a

Molecular Weight (kDa) :

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 5% FCS

Research Area :

Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

Notes :

Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY.

more info or order :

Ximbio product webpage