Anti-Integrin aV [P2W7] | Ximbio 151140 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Integrin aV [P2W7]

catalog :

151140

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3685

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Integrin aV [P2W7]

Catalogue Number :

151140

Applications :

FACS IHC IF IP WB

Antigen/Gene or Protein Targets :

Integrin alpha V (CD51)

Reactivity :

Human

Relevance :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin aV associates with integrin b3 to form the osteoclast functional antigen (vitronectin receptor). Integrin aV is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin aV increases with melanoma progression.

Host :

Mouse

Immunogen :

Ocular melanoma cell line (V+B2) a clone expressing high levels of alpha-v, beta-1

Subclass :

IgG1

Positive Control :

A375M melanoma

Molecular Weight (kDa) :

150-160

Recommended Growing Conditions :

DMEM + 5% FCS

Research Area :

Stem Cell Biology

Notes :

Human alpha v is about 150-160kDa under non-reducing conditions. Under reducing conditions it is cleaved into 2 bands of about 125-130kDa +20-25kDa.

more info or order :

Ximbio product webpage