Anti-Keratin5 & 14 [LH8] | Ximbio 151116 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Keratin5 & 14 [LH8]

catalog :

151116

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3852

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

more info or order :

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product information

Name :

Anti-Keratin5 & 14 [LH8]

Catalogue Number :

151116

Applications :

IHC IF

Antigen/Gene or Protein Targets :

Keratin 5 & 14

Reactivity :

Human

Relevance :

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 5 and 14 are the predominant keratins in basal layer keratinocytes in stratified epithelia. Their expression is restricted to basal cells and are found on all keratinocytes. Keratin 14 is one of two keratins that distinguish stratifying epithelial cell types from simple epithelial cell types. Mutations in keratin 5 or 14 cause the skin blistering disorder epidermolysis bullosa simplex. LH8 may be useful as a basal cell marker and myoepithelial marker in stratified squamous or mixed epithelia.

Host :

Mouse

Immunogen :

The 50,000 Mr band (including K14) was cut from an SDS-polyacrylamide gel and Triton X-100 extracted cytoskeleton pellet from cultured human foreskin keratinocytes.

Subclass :

IgM

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 5% FCS

Strain :

Balb/c

Research Area :

Cell Signaling & Signal Transduction

Notes :

For immunohistochemistry, use unfixed frozen sections with this antibody.

more info or order :

Ximbio product webpage