Anti-Integrin a2 [HAS-4] | Ximbio 151105 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Integrin a2 [HAS-4]

catalog :

151105

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3655

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Integrin a2 [HAS-4]

Catalogue Number :

151105

Applications :

FACS IHC IF IP

Antigen/Gene or Protein Targets :

Integrin a2 (CD49b)

Synonyms :

Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR

Reactivity :

Human

Relevance :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin b1 (CD29) to form the heterodimer integrin a2b1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-4 co-precipitates integrin a2b1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.

Host :

Mouse

Subclass :

IgG2a

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM + 5% FCS

Research Area :

Adhesion, Cancer, Cell Signaling & Signal Transduction, Metabolism

more info or order :

Ximbio product webpage