product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-Integrin aM [ICRF44]
catalog :
151052
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3684
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, FACS
more info or order :
Ximbio product webpage
product information
Name :
Anti-Integrin aM [ICRF44]
Catalogue Number :
151052
Applications :
FACS IHC IP WB
Antigen/Gene or Protein Targets :
Integrin alpha M (CD11b; Mac-1a subunit)
Synonyms :
Integrin Subunit Alpha M; Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Macrophage Antigen Alpha Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit 3; Macrophage Antigen Alpha Polypeptide 3; Neutrophil Adherence Receptor 4; Antigen CD11b (P170) 3; CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A
Reactivity :
Human and Primate
Relevance :
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha M (CD11B) is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections. ICRF 44 blocks some functions of Mac-1.
Host :
Mouse
Immunogen :
Rheumatoid synovial cells and human monocytes.
Subclass :
IgG1
Positive Control :
Monocytes or neutrophils
Molecular Weight (kDa) :
160
Myeloma Used :
Sp2/0-Ag14
Recommended Growing Conditions :
DMEM + 5% FCS
Strain :
Balb/c
Research Area :
Adhesion
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com