product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-Integrin aVb3 [23C6]
catalog :
151039
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3685
reactivity :
human
application :
immunohistochemistry, immunoprecipitation, FACS
more info or order :
Ximbio product webpage
product information
Name :
Anti-Integrin aVb3 [23C6]
Catalogue Number :
151039
Applications :
FACS IHC IP Fn
Antigen/Gene or Protein Targets :
Integrin alpha V ß3 (CD51/61; Osteoclast Functional Antigen)
Reactivity :
Human
Relevance :
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
Host :
Mouse
Immunogen :
A cell suspension containing osteoclasts from osteoclastomas.
Subclass :
IgG1
Positive Control :
Tonsil
Molecular Weight (kDa) :
125/124, 150
Myeloma Used :
P3X63Ag8.653
Recommended Growing Conditions :
DMEM + 5% FCS
Strain :
Balb/c
Research Area :
Adhesion, Cancer, Cardiovascular
Notes :
125/124 kDa (reduced), 150kDa (non-reduced)
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com