antibody

PE-Cy5.5 Anti-Human CD8a Antibody(OKT-8)

PEC55-30006

20T/100T

148/358 USD

monoclonal

mouse

PE-Cy5.5

OKT-8

PE-Cy5.5 Anti-Human CD8a Antibody(OKT-8)

Flow cytometry Antibodies

Mouse

Monoclonal

PE-Cy5.5

OKT-8

20T/100T

148/358 USD

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the ?3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

CD8A MAL T-cell surface glycoprotein CD8 alpha chain T-lymphocyte differentiation antigen T8/Leu-2

Human CD8a

Research use only

FC

PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8? for 12 months (Avoid repeated freeze / thaw cycles.)