antibody

PE-Cy7 Anti-Human CD274/PD-L1 Antibody(29E.2A3)

PC7-30044

20T/100T

256/598 USD

monoclonal

mouse

PE/Cy7

29E.2A3

PE-Cy7 Anti-Human CD274/PD-L1 Antibody(29E.2A3)

Flow cytometry Antibodies

Mouse

Monoclonal

PE-Cy7

29E.2A3

20T/100T

256/598 USD

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-? production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

B7H1PD-L1PDCD1L1PDCD1LG1PDL1 B7 homolog 1 B7-H B7-H1 Programmed cell death ligand 1

Human CD274

Research use only

FC

PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8? for 12 months (Avoid repeated freeze / thaw cycles.)