antibody

PE-Cy5 Anti-Human CD197/CCR7 Antibody(G043H7)

PC5-30090

20T/100T

266/772 USD

monoclonal

mouse

PE-Cy5

G043H7

PE-Cy5 Anti-Human CD197/CCR7 Antibody(G043H7)

Flow cytometry Antibodies

Mouse

Monoclonal

PE-Cy5

G043H7

20T/100T

266/772 USD

CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naive T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

EBI1EVI1 CCR-7 CDw197 CMKBR7

Human CD197/CCR7

Research use only

FC

PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8? for 12 months (Avoid repeated freeze / thaw cycles.)