antibody

RAB8A Rabbit Polyclonal

FNab07045

100 ug

polyclonal

domestic rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, immunoprecipitation

RAB8A Rabbit Polyclonal

Antibody

Rabbit

Polyclonal

Unconjugated

IgG

100 ug

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.

MEL antibody, RAB8 antibody,RAB8A Antibody

RAB8A antibody: Rabbit Polyclonal antibody to RAB8A

RAB8A, member RAS oncogene family

Human, Mouse ,Rat

≥95% as determined by SDS-PAGE

ELISA, WB, IF, IP

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)