antibody

RAB5A Rabbit Polyclonal

FNab07038

100 ug

polyclonal

domestic rabbit

nonconjugated

western blot, ELISA, immunohistochemistry

RAB5A Rabbit Polyclonal

Antibody

Rabbit

Polyclonal

Unconjugated

IgG

100 ug

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell- containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

RAB5 antibody,RAB5A Antibody

RAB5A antibody: Rabbit Polyclonal antibody to RAB5A

RAB5A, member RAS oncogene family

Human, Mouse ,Rat

≥95% as determined by SDS-PAGE

ELISA, IHC, WB, IP，IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)