antibody

HIF1a Rabbit Polyclonal

FNab03859

100 ug

polyclonal

domestic rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

HIF1a Rabbit Polyclonal

Antibody

Rabbit

Polyclonal

Unconjugated

IgG

100 ug

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5′-[AG]CGTG-3′ within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

BHLHE78 antibody, MOP1 antibody, PASD8 antibody,HIF1a Antibody

HIF1a antibody: Rabbit Polyclonal antibody to HIF1a

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Human, Mouse ,Rat

≥95% as determined by SDS-PAGE

ELISA, IHC, IF, FC, WB

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)