antibody

CXCR4 Mouse Monoclonal

FNab02103

100 ug

monoclonal

mouse

nonconjugated

western blot, ELISA, flow cytometry

CXCR4 Mouse Monoclonal

Antibody

Mouse

Monoclonal

Unconjugated

IgG2a

100 ug

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:9427609, PubMed:10074122, PubMed:10756055). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).

CXCR4 Antibody

CXCR4 antibody: Mouse Monoclonal antibody to CXCR4

chemokine (C-X-C motif) receptor 4

Human, Mouse

≥95% as determined by SDS-PAGE

ELISA, WB, FC

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)