antibody

CSK Mouse Monoclonal

FNab02017

100 ug

monoclonal

mouse

nonconjugated

western blot, ELISA, immunocytochemistry

CSK Mouse Monoclonal

Antibody

Mouse

Monoclonal

Unconjugated

IgG1

100 ug

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

CSK Antibody

CSK antibody: Mouse Monoclonal antibody to CSK

c-src tyrosine kinase

Human

≥95% as determined by SDS-PAGE

ELISA, WB, IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)