antibody

BCL2L1 Mouse Monoclonal

FNab00843

100 ug

monoclonal

mouse

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry

BCL2L1 Mouse Monoclonal

Antibody

Mouse

Monoclonal

Unconjugated

IgG2a

100 ug

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.

BCL2L antibody, BCLX antibody,BCL2L1 Antibody

BCL2L1 antibody: Mouse Monoclonal antibody to BCL2L1

BCL2-like 1

Human

≥95% as determined by SDS-PAGE

ELISA, WB, IHC, IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)