antibody

BBS2 Mouse Monoclonal

FNab00816

100 ug

monoclonal

mouse

nonconjugated

western blot, ELISA, immunocytochemistry

BBS2 Mouse Monoclonal

Antibody

Mouse

Monoclonal

Unconjugated

IgG2a

100 ug

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

BBS2 Antibody

BBS2 antibody: Mouse Monoclonal antibody to BBS2

Bardet-Biedl syndrome 2

Human, Dog

≥95% as determined by SDS-PAGE

ELISA, WB, IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)