antibody

ATF4 Mouse Monoclonal

FNab00663

100 ug

monoclonal

mouse

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry

ATF4 Mouse Monoclonal

Antibody

Mouse

Monoclonal

Unconjugated

IgG1

100 ug

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).

CREB2 antibody, TXREB antibody,ATF4 Antibody

ATF4 antibody: Mouse Monoclonal antibody to ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

Human, Mouse

≥95% as determined by SDS-PAGE

ELISA, IHC, WB, IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)