antibody

ALK,CD246 Mouse Monoclona

FNab00310

100 ug

monoclonal

mouse

nonconjugated

western blot, ELISA, immunohistochemistry

ALK,CD246 Mouse Monoclona

Antibody

Mouse

Monoclonal

Unconjugated

IgG2a

100 ug

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).

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ALK,CD246 antibody: Mouse Monoclonal antibody to ALK,CD246

anaplastic lymphoma receptor tyrosine kinase

Human

≥95% as determined by SDS-PAGE

ELISA, IHC, WB

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)