antibody

FineTest(R)700 Anti-Human CD279/PD-1 Antibody(EH12.2H7)

F700-30036

20T/100T

236/590 USD

monoclonal

mouse

nonconjugated

EH12.2H7

FineTest(R)700 Anti-Human CD279/PD-1 Antibody(EH12.2H7)

Flow cytometry Antibodies

Mouse

Monoclonal

FineTest(R)700

EH12.2H7

20T/100T

236/590 USD

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

PD1 PDCD1 Protein PD-1 hPD-1

Human CD279/PD

Research use only

FC

PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8? for 12 months (Avoid repeated freeze / thaw cycles.)