antibody

FineTest(R)647 Anti-Mouse CD150/SLAM Antibody(TC15-12F12.2)

F647-09790

50T/100T

188/278 USD

monoclonal

rat

nonconjugated

TC15-12F12.2

FineTest(R)647 Anti-Mouse CD150/SLAM Antibody(TC15-12F12.2)

Flow cytometry Antibodies

Rat

Monoclonal

FineTest(R)647

TC15-12F12.2

50T/100T

188/278 USD

CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-? production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.

CD 150 Signaling lymphocytic activation molecule Slam Slamf1

Mouse CD150/SLAM

Research use only

FC

PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8? for 12 months (Avoid repeated freeze / thaw cycles.)