product summary
company name :
Vector Laboratories
product type :
antibody
product name :
Ki67
catalog :
VP-RM04
conjugate :
nonconjugated
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 69
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2h
Yao W, Rose J, Wang W, Seth S, Jiang H, Taguchi A, et al. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4b
Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al. MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer. Breast Cancer Res. 2019;21:27 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4f
Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5c, 5e
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5e
Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5d
Liao L, Song M, Li X, Tang L, Zhang T, Zhang L, et al. E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2017;77:2090-2101 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7f
Halbrook C, Wen H, Ruggeri J, Takeuchi K, Zhang Y, di Magliano M, et al. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis. Cell Mol Gastroenterol Hepatol. 2017;3:99-118 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s8
Fallahi Sichani M, Becker V, Izar B, Baker G, Lin J, Boswell S, et al. Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Mol Syst Biol. 2017;13:905 pubmed publisher
  • immunocytochemistry; mouse; fig 3h
Miyoshi H, VanDussen K, Malvin N, Ryu S, Wang Y, Sonnek N, et al. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J. 2017;36:5-24 pubmed publisher
  • immunocytochemistry; mouse; fig 3h
Matthews S, Sartorius C. Steroid Hormone Receptor Positive Breast Cancer Patient-Derived Xenografts. Horm Cancer. 2017;8:4-15 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s3
Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
  • immunocytochemistry; human; fig 2
Li Y, Zhang W, Chang L, Han Y, Sun L, Gong X, et al. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016;7:478-88 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
  • flow cytometry; human; fig 1
Guinot A, Oeztuerk Winder F, Ventura J. miR-17-92/p38? Dysregulation Enhances Wnt Signaling and Selects Lgr6+ Cancer Stem-like Cells during Lung Adenocarcinoma Progression. Cancer Res. 2016;76:4012-22 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; loading ...; fig 2b
Tirosh I, Izar B, Prakadan S, Wadsworth M, Treacy D, Trombetta J, et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016;352:189-96 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig s4a
Lim S, Yuzhalin A, Gordon Weeks A, Muschel R. Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells. Oncogene. 2016;35:5735-5745 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig st1
Kaur A, Webster M, Marchbank K, Behera R, Ndoye A, Kugel C, et al. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016;532:250-4 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 3
Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, et al. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Sci Rep. 2016;6:22996 pubmed publisher
  • immunocytochemistry; human
Kim J, Lee H, Park K, Choi Y, Nam J, Hong I. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. Oncotarget. 2016;7:20395-409 pubmed publisher
  • immunohistochemistry; human; fig 7
Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, et al. Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells. Oncotarget. 2016;7:5366-82 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 2
Creedon H, Balderstone L, Muir M, Balla J, Gómez Cuadrado L, Tracey N, et al. Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer. Dis Model Mech. 2016;9:131-40 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong R, Miller K, et al. Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discov. 2016;6:188-201 pubmed publisher
  • immunohistochemistry; mouse; fig 2
Hu X, Garcia C, Fazli L, Gleave M, Vitek M, Jansen M, et al. Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. Sci Rep. 2015;5:15182 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 5b
Ramcharan R, Aleksic T, Kamdoum W, Gao S, Pfister S, Tanner J, et al. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. Oncotarget. 2015;6:39877-90 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 6
Ruscetti M, Quach B, Dadashian E, Mulholland D, Wu H. Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis. Cancer Res. 2015;75:2749-59 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; fig 2
Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree J, et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci. 2015;18:674-82 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s3b
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med. 2015;21:71-5 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Serinagaoglu Y, Paré J, Giovannini M, Cao X. Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol. 2015;398:97-109 pubmed publisher
  • immunohistochemistry; human; fig 4
Yi T, Kabha E, Papadopoulos E, Wagner G. 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget. 2014;5:6028-37 pubmed
  • immunohistochemistry; mouse; 1:200
Konsavage W, Yochum G. The myc 3' wnt-responsive element suppresses colonic tumorigenesis. Mol Cell Biol. 2014;34:1659-69 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Foth M, Ahmad I, van Rhijn B, van der Kwast T, Bergman A, King L, et al. Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. J Pathol. 2014;233:148-58 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Konsavage W, Jin G, Yochum G. The Myc 3' Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol. 2012;32:3891-902 pubmed publisher
Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, et al. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nat Commun. 2019;10:3329 pubmed publisher
Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, et al. Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. 2019;: pubmed publisher
Khuu M, Pagan C, Nallamothu T, Hevner R, Hodge R, Ramirez J, et al. Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus. J Neurosci. 2019;39:1320-1331 pubmed publisher
Kensler K, Beca F, Baker G, Heng Y, Beck A, Schnitt S, et al. Androgen receptor expression in normal breast tissue and subsequent breast cancer risk. NPJ Breast Cancer. 2018;4:33 pubmed publisher
Hu P, Liu J, Zhao J, Wilkins B, Lupino K, Wu H, et al. Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts. Genes Dev. 2018;32:1344-1357 pubmed publisher
Holmes G, O Rourke C, Motch Perrine S, Lu N, van Bakel H, Richtsmeier J, et al. Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development. 2018;145: pubmed publisher
Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher
Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, et al. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018;560:661-665 pubmed publisher
Mackie D, Al Mutairi F, Davis R, Kechele D, Nielsen N, Snyder J, et al. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. J Exp Med. 2018;215:2339-2353 pubmed publisher
Xiong Y, Torsoni A, Wu F, Shen H, Liu Y, Zhong X, et al. Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. elife. 2018;7: pubmed publisher
Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, et al. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018;9:945-965 pubmed publisher
Gould J, Smith P, Airey C, Mort E, Airey L, Warricker F, et al. Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory. Proc Natl Acad Sci U S A. 2018;115:E7398-E7407 pubmed publisher
Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, et al. Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Aging Cell. 2018;17:e12765 pubmed publisher
Cimino P, Kim Y, Wu H, Alexander J, Wirsching H, Szulzewsky F, et al. Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma. Genes Dev. 2018;32:512-523 pubmed publisher
Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, et al. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018;9:333-350 pubmed publisher
Rogala A, Schoenborn A, Fee B, Cantillana V, Joyce M, Gharaibeh R, et al. Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. Dis Model Mech. 2018;11: pubmed publisher
Tammela T, Sanchez Rivera F, Cetinbas N, Wu K, Joshi N, Helenius K, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. 2017;545:355-359 pubmed publisher
Boutin A, Liao W, Wang M, Hwang S, Karpinets T, Cheung H, et al. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev. 2017;31:370-382 pubmed publisher
Dey P, Baddour J, Muller F, Wu C, Wang H, Liao W, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017;542:119-123 pubmed publisher
Zhang Q, Zhao W, Ye C, Zhuang J, Chang C, Li Y, et al. Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis. Oncotarget. 2015;6:37335-48 pubmed publisher
Samal S, Routray S, Veeramachaneni G, Dash R, Botlagunta M. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015;5:9982 pubmed publisher
Lee Y, Dominy J, Choi Y, Jurczak M, Tolliday N, Camporez J, et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014;510:547-51 pubmed publisher
Feliciano D, Zhang S, Nasrallah C, Lisgo S, Bordey A. Embryonic cerebrospinal fluid nanovesicles carry evolutionarily conserved molecules and promote neural stem cell amplification. PLoS ONE. 2014;9:e88810 pubmed publisher
Chen Z, Morris D, Jiang L, Liu Y, Rui L. SH2B1 in ?-cells regulates glucose metabolism by promoting ?-cell survival and islet expansion. Diabetes. 2014;63:585-95 pubmed publisher
Nakaya T, Ishiguro K, Belzil C, Rietsch A, Yu Q, Mizuno S, et al. p600 Plays Essential Roles in Fetal Development. PLoS ONE. 2013;8:e66269 pubmed publisher
Jeselsohn R, Werner L, Regan M, Fatima A, Gilmore L, Collins L, et al. Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response. PLoS ONE. 2013;8:e64225 pubmed publisher
Chen Y, Chen J, Loo A, Jaeger S, Bagdasarian L, Yu J, et al. Targeting HSF1 sensitizes cancer cells to HSP90 inhibition. Oncotarget. 2013;4:816-29 pubmed
Martínez Abadías N, Holmes G, Pankratz T, Wang Y, Zhou X, Jabs E, et al. From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome. Dis Model Mech. 2013;6:768-79 pubmed publisher
Collins M, Brisset J, Zhang Y, Bednar F, Pierre J, Heist K, et al. Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. PLoS ONE. 2012;7:e49707 pubmed publisher
Katz S, Fisher J, Correll M, Bronson R, Ligon K, Walensky L. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene. 2013;32:4078-85 pubmed publisher
Liu J, Hettmer S, Milsom M, Hofmann I, Hua F, Miller C, et al. Induction of histiocytic sarcoma in mouse skeletal muscle. PLoS ONE. 2012;7:e44044 pubmed publisher
Nagel J, Geiger B, Karagiannis A, Gras Miralles B, Horst D, Najarian R, et al. Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone. PLoS ONE. 2012;7:e41914 pubmed publisher
Chhatriwala M, Cipolat S, Sevilla L, Nachat R, Watt F. Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. J Invest Dermatol. 2012;132:1977-87 pubmed publisher
Chen X, Lepier A, Berninger B, Tolkovsky A, Herbert J. Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus. PLoS ONE. 2012;7:e31547 pubmed publisher
Ahmad I, Patel R, Liu Y, Singh L, Taketo M, Wu X, et al. Ras mutation cooperates with ?-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2011;2:e124 pubmed publisher
Chen X, Tolkovsky A, Herbert J. Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat. PLoS ONE. 2011;6:e17072 pubmed publisher
Zhu L, Gibson P, Currle D, Tong Y, Richardson R, Bayazitov I, et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009;457:603-7 pubmed publisher
Zheng H, Ying H, Yan H, Kimmelman A, Hiller D, Chen A, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008;455:1129-33 pubmed publisher
Dylla S, Beviglia L, Park I, Chartier C, Raval J, Ngan L, et al. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS ONE. 2008;3:e2428 pubmed publisher
company information
Vector Laboratories
30 Ingold Road Burlingame, CA 94010
vector@vectorlabs.com
http://www.vectorlabs.com
headquarters: United States
Manufacturer and retailer of protein and nucleic acid labeling and detection reagents for over 35 years.