TGM2 (TGase-2, Transglutaminase-2, TGC, Protein-glutamine gamma-glutamyltransferase 2, Tissue Transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H) | US Biological T8260-03M product information

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product summary

company name :

US Biological

product type :

antibody

product name :

TGM2 (TGase-2, Transglutaminase-2, TGC, Protein-glutamine gamma-glutamyltransferase 2, Tissue Transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H)

catalog :

T8260-03M

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

T8260-03M

Product wo Prefix :

TGM2 (TGase-2, Transglutaminase-2, TGC, Protein-glutamine gamma-glutamyltransferase 2, Tissue Transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

Transglutaminase(TGase) catalyses the crosslink of proteins by forming -(-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal -sandwich, catalytic core and two C-terminal -barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including A peptide, -amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:5000 Optimal dilutions to be determined by the researcher. Positive Control: U87MG Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Immunogen :

Recombinant corresponding to human TGM2 expressed in E.coli.

Specificity :

Recognizes human TGM2.

Purity :

Purified by Protein A affinity chromatography.

Form :

Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol. Purity: Purified by Protein A affinity chromatography. Immunogen: Recombinant corresponding to human TGM2 expressed in E.coli. Specificity: Recognizes human TGM2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

1. Griffin, M. et al. (2002) Biochem. J. 368, 377-396. 2. Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. 3. Kim, SY. et al. (2002) Neurochem. Int. 40, 85-103.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/9/T8260-03M_1.jpg