antibody

TORC2 (CREB-regulated Transcription Coactivator 2, Transducer of Regulated cAMP Response Element-binding Protein 2, TORC-2, Transducer of CREB Protein 2, CRTC2)

T8067-21E

100 ug

polyclonal

domestic goat

nonconjugated

human, mouse, rat

TORC2 (CREB-regulated Transcription Coactivator 2, Transducer of Regulated cAMP Response Element-binding Protein 2, TORC-2, Transducer of CREB Protein 2, CRTC2)

goat

Pab

Antibodies

100 ug

IgG

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Hormonal and energy-sensing pathways converge on the coactivator TORC2 (transducer of regulated CREB activity 2) to modulate glucose output. Sequestered in the cytoplasm under feeding conditions, TORC2 is dephosphorylated and transported to the nucleus where it enhances CREB-dependent transcription in response to fasting stimuli. Conversely, signals that activate AMPK attenuate the gluconeogenic programme by promoting TORC2 phosphorylation and blocking its nuclear accumulation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.3-1ug/ml, observed in lysates of cell line Jurkat on ~85kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Bo Ca Hu Mo Po Rt

Synthetic peptide corresponding to C-EFQSPLHSPLDSSR, from human CRTC2, at the internal region of the protein (NP_859066.1).

Recognizes human CRTC2. Species sequence homology: Bovine, canine, mouse, porcine and rat.

Purified by immunoaffinity chromatography

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5mg/ml

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-EFQSPLHSPLDSSR, from human CRTC2, at the internal region of the protein (NP_859066.1). Specificity: Recognizes human CRTC2. Species sequence homology: Bovine, canine, mouse, porcine and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E WB

-20°C

https://usbio-images.r.worldssl.net/prodimages/14/T8067-21E_1.jpg