THRB (Thyroid Hormone Receptor beta, Nuclear Receptor Subfamily 1 Group A Member 2, c-erbA-2, c-erbA-beta, ERBA2, NR1A2, THR1) | US Biological T5349-01K product information

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product summary

company name :

US Biological

product type :

antibody

product name :

THRB (Thyroid Hormone Receptor beta, Nuclear Receptor Subfamily 1 Group A Member 2, c-erbA-2, c-erbA-beta, ERBA2, NR1A2, THR1)

catalog :

T5349-01K

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

product information

Catalog Number :

T5349-01K

Product wo Prefix :

THRB (Thyroid Hormone Receptor beta, Nuclear Receptor Subfamily 1 Group A Member 2, c-erbA-2, c-erbA-beta, ERBA2, NR1A2, THR1)

Host :

goat

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

Thyroid hormone receptors (THRs) are 55kD ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding THRs identified to date, TRa and TRb, have been mapped to human chromosomes 17 and 3, respectively. THRs bind to thyroid hormone response elements (THREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo- L-thyronine (T-3). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.3-1ug/ml, observed in human bone marrow lysates on 50+60kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Ca Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to C-REELQKSIGHKP, from human THRB, at the internal region of the protein (NP_000452.2).

Specificity :

Recognizes human THRB. Species sequence homology: Canine, mouse and rat.

Purity :

Purified by immunoaffinity chromatography

Form :

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-REELQKSIGHKP, from human THRB, at the internal region of the protein (NP_000452.2). Specificity: Recognizes human THRB. Species sequence homology: Canine, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E WB

Storage Temperature :

-20°C

Reference :

1. Kim JH, Park TS, Baek HS, Kim GH, Yoo HW, Park JH. A newly identified insertion mutation in the thyroid hormone receptor-beta gene in a Korean family with generalized thyroid hormone resistance. J Korean Med Sci. 2007 Jun;22(3):560-3.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/9/T5349-01K_1.jpg