STAT6, phosphorylated (Tyr641) (Signal Transducer and Activator of Transcription 6, IL-4 Stat) | US Biological S7972-47A product information

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product summary

company name :

US Biological

product type :

antibody

product name :

STAT6, phosphorylated (Tyr641) (Signal Transducer and Activator of Transcription 6, IL-4 Stat)

catalog :

S7972-47A

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

product information

Catalog Number :

S7972-47A

Product wo Prefix :

STAT6, phosphorylated (Tyr641) (Signal Transducer and Activator of Transcription 6, IL-4 Stat)

Host :

rabbit

Product Type :

Pab

Antigen Modification :

Phosphorylated

Category :

Antibodies

Size1 :

100 ug

Isotype :

IgG

Desc1 :

Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3b appears to be activated by both while Stat3a is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: 20ug/ml Western Blot: 1-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo

Immunogen :

Synthetic phosphopeptide corresponding to Tyr641 from human Stat6.

Specificity :

Recognizes human Stat6 at ~110kD. Species Crossreactivity: mouse.

Purity :

Purified by affinity chromatography.

Form :

Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide, 50% glycerol.

Concentration :

~0.5mg/ml

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide, 50% glycerol. Purity: Purified by affinity chromatography. Immunogen: Synthetic phosphopeptide corresponding to Tyr641 from human Stat6. Specificity: Recognizes human Stat6 at ~110kD. Species Crossreactivity: mouse. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

IHC WB

Storage Temperature :

-20°C