STAT 4 (Signal Transducer and Activator of Transcription 4) | US Biological S7972-01C product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

STAT 4 (Signal Transducer and Activator of Transcription 4)

catalog :

S7972-01C

quantity :

100 ul

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

C46B10

The same clone is also sold as:

Cell Signaling Technology: 2653

reactivity :

human

product information

Catalog Number :

S7972-01C

Product wo Prefix :

STAT 4 (Signal Transducer and Activator of Transcription 4)

Host :

rabbit

Product Type :

Mab

Category :

Antibodies

Size1 :

100 ul

Clone # USB :

C46B10

Isotype :

IgG

Desc1 :

The Jak-Stat signaling pathway is utilized by a large number of cytokines, growth factors and hormones (1). Receptor-mediated tyrosine phosphorylation of Jak family members triggers phosphorylation of Stat proteins resulting in their nuclear translocation, binding to specific DNA elements and subsequent activation of transcription. The remarkable range and specificity of responses regulated by the Stats is determined in part by the tissue-specific expression of different cytokine receptors, Jaks and Stats as well as by the combinatorial coupling of various Stat members to different receptors. Stat4 is predominantly expressed in the spleen, thymus and testis and has been most extensively investigated as the mediator of IL-12 responses (3-8). Applications: Suitable for use in Western Blot and ChIP. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 ChIP: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to residues surrounding Lys151 of Stat4.

Specificity :

Recognizes endogenous levels of total Stat4 protein. Species Crossreactivity: Human, mouse and rat.

Purity :

Purified

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Mab Isotype: IgG Clone No: C46B10 Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol. Purity: Purified Immunogen: Synthetic peptide corresponding to residues surrounding Lys151 of Stat4. Specificity: Recognizes endogenous levels of total Stat4 protein. Species Crossreactivity: Human, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

ChIP WB

Storage Temperature :

-20°C

Reference :

1 Darnell, J.E. et al. (1994) Science 264, 1415-1421. 2 Leonard, W.J. and O'Shea, J.J. (1998) Annu. Rev. Immunol. 16, 293-322. 3 Zhong, Z. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4806-4810. 4 Yamamoto, K. et al. (1994) Mol. Cell Biol. 14, 4342-4349. 5 Jacobson, N.G. et al. (1995) J. Exp. Med. 181, 1755-1762. 6 Bacon, C.M. et al. (1995) Proc. Natl. Acad. Sci. USA 92, 7307-7311. 7 Thierfelder, W.E. et al. (1996) Nature 382, 171-174. 8 Kaplan, M.H. et al. (1996) Nature 382, 174-177.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/35/S7972-01C_1.jpg