SHP 2 (SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11) | US Biological S1013-29A product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

US Biological

product type :

antibody

product name :

SHP 2 (SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11)

catalog :

S1013-29A

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

S1013-29A

Product wo Prefix :

SHP 2 (SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11)

Host :

rabbit

Product Type :

Pab

Category :

Antibodies

Size1 :

100 ul

Isotype :

IgG

Desc1 :

SHP2 (SHPTP-1, SHPTP-2, PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp, PTPN11) is a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death (1). Activation of SHP 2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines (2). In addition to its role in Gab1-mediated Erk activation, SHP 2 attenuates EGF-dependent PI3 kinase activation by dephosphorylating Gab1 p85 binding sites (3). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Also Available: S1013-29: SHP 2 (SHPTP-2) Pab Rb xMo S1013-29A: SHP 2 Pab Rb xHu S1013-29B: SHP 2 (224-529), protein tyrosine phosphatase, catalytic domain, Recombinant, Human (SHPTP-2, PTPN11) S1013-29E: SHP 2, phosphorylated (Tyr542) Pab Rb xHu S1013-29F: SHP 2, phosphorylated (Tyr580) Pab Rb xHu

Calc Crossreactivity :

Hu Mo Rt

Immunogen :

Synthetic peptide corresponding to residues surrounding the N-terminal domain of human SHP-2 (KLH coupled).

Specificity :

Recognizes endogenous levels of human SHP-2 independent of phosphorylation. Species crossreactivity: mouse and rat.

Purity :

Purified by protein A and peptide affinity chromatography.

Form :

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, BSA, 50% glycerol.

Concentration :

Not determined

Desc2 :

Product Type: Pab Isotype: IgG Host: rabbit Source: human Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, BSA, 50% glycerol. Purity: Purified by protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding the N-terminal domain of human SHP-2 (KLH coupled). Specificity: Recognizes endogenous levels of human SHP-2 independent of phosphorylation. Species crossreactivity: mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

Storage Temperature :

-20°C

Reference :

(1) Qu, C.K. (2000) Cell Res. 10, 279–288. (2) Maroun, C.R. et al. (2000) Mol. Cell. Biol. 20, 8513–8525. (3) Zhang, S.Q. et al. (2002) Mol. Cell. Biol. 22, 4062–4072.

Picture 1 File Name :

https://usbio-images.r.worldssl.net/prodimages/37/S1013-29A_1.jpg